CRISPRi-Linked Multi-Module Feedback Loops
Integrating dCas9 into the E. coli genome to implement CRISPR interference across two gene modules — mitigating winner-take-all resource competition and improving synthetic circuit predictability.
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Hi, there!
I'm Sadikshya, and I like to build at the intersection of biology and engineering.
I'm a PhD candidate in Biological Design at Arizona State University, where I work on synthetic gene circuits, CRISPR interference, and biomolecular condensates. Outside the lab, I help run Nucleate Arizona and enjoy mentoring early-career scientists.
Latest Work
Phase Separation to Resolve Growth-Related Circuit Failures
Engineering biomolecular condensates as a strategy to stabilize synthetic gene circuits under growth feedback. Published in Cell (2025).
Read MoreEvolutionary History of the Ku Protein
A phylogenetic study of the DNA repair protein Ku across eukaryotes and prokaryotes, using sequence data from NCBI and OrthoDB. Published in PLOS ONE (2025).
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